Search results for "Mixed tumor"

showing 3 items of 3 documents

Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives

2017

Carcinosarcomas (CS) in gynecology are very infrequent and represent only 2–5% of uterine cancers. Despite surgical cytoreduction and subsequent chemotherapy being the primary treatment for uterine CS, the overall five-year survival rate is 30 ± 9% and recurrence is extremely common (50–80%). Due to the poor prognosis of CS, new strategies have been developed in the last few decades, targeting known dysfunctional molecular pathways for immunotherapy. In this paper, we aimed to gather the available evidence on the latest therapies for the treatment of CS. We performed a systematic review using the terms “uterine carcinosarcoma”, “uterine Malignant Mixed Müllerian Tumors”, “target therapies”,…

0301 basic medicineOncologyPathologyAngiogenesisCarcinosarcomas epigenetics genetics immunotherapy uterine cancer.medicine.medical_treatmentReviewEpigenesis Geneticlcsh:Chemistry0302 clinical medicineCarcinosarcomaAntibodies BispecificCarcinosarcomas Epigenetics Genetics Immunotherapy Uterine cancerMedicinegeneticsMolecular Targeted Therapylcsh:QH301-705.5Human Epidermal Growth Factor Receptor 2SpectroscopyNeovascularization PathologicGeneral MedicineEpithelial Cell Adhesion MoleculePrognosisComputer Science ApplicationsErbB ReceptorsSurvival Rate030220 oncology & carcinogenesisUterine NeoplasmsFemaleImmunotherapymedicine.medical_specialtyPoor prognosisMixed Tumor MullerianCatalysisuterine cancerInorganic Chemistry03 medical and health sciencesCancer stem cellInternal medicineBiomarkers TumorHumansTarget therapyPhysical and Theoretical ChemistrycarcinosarcomasMolecular BiologySurvival rateChemotherapyepigeneticsbusiness.industryOrganic ChemistryImmunotherapy030104 developmental biologylcsh:Biology (General)lcsh:QD1-999businessInternational Journal of Molecular Sciences
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The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).

2016

OBJECTIVE: Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival. METHODS: The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology. RESULTS: During 2005-2009, type II epithelial tumours…

Epidemiology; Histology; Morphology; Ovarain cancer; Worldwide0301 basic medicineOncologyPathologyendocrine system diseasesEpidemiologySex Cord-Gonadal Stromal TumorsCarcinoma Ovarian Epithelial0302 clinical medicineNeoplasmsEpidemiologyNeoplasms Glandular and EpithelialOvarian Neoplasmseducation.field_of_studyEpidemiology; Histology; Morphology; Ovarain cancer; Worldwide; Adolescent; Adult; Aged; Female; Humans; Middle Aged; Neoplasms Germ Cell and Embryonal; Neoplasms Glandular and Epithelial; Ovarian Neoplasms; Sex Cord-Gonadal Stromal Tumors; Oncology; Obstetrics and GynecologyGlandular and EpithelialObstetrics and GynecologyMiddle AgedNeoplasms Germ Cell and Embryonalfemale genital diseases and pregnancy complicationsTransitional cell carcinomaOncology030220 oncology & carcinogenesisClear cell carcinomaFemaleWorldwideHumanMorphologyAdultendocrine systemmedicine.medical_specialtyHistologyAdolescentEpidemiology ; Histology ; Morphology ; Ovarain cancer ; WorldwidePopulationSocio-culturale03 medical and health sciencesInternal medicinemedicineHumansSex Cord-Gonadal Stromal TumorseducationAgedMixed tumorbusiness.industryOvarian NeoplasmSex Cord-Gonadal Stromal TumorHistologymedicine.diseaseOvarain cancerEpidemiology; Histology; Morphology; Ovarain cancer; Worldwide;030104 developmental biologyGerm Cell and EmbryonalOvarian cancerbusinessGynecologic oncology
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Cytogenetic findings in malignant mixed mesodermal tumors of the uterus.

1997

Abstract Cytogenetic analyses of four malignant mixed mesodermal tumors (MMMT) of the uterus are reported, of which one was of the homologous type and three of the heterologous type. Karyotypic analyses were obtained in two cases from original tumors and in two cases from tumors xenotransplanted into nude mice. The karyotype of the homologous MMMT was normal in three different passages of a nude mice xenograft line established from the primary tumor. The heterologous tumors showed normal karyotype in one case and hyperdiploid and near triploid range with extensive numerical and structural rearrangements in two cases. Deletion of chromosome 1 at p32, and deletion of chromosome 11 at q13 were…

Cancer ResearchPathologymedicine.medical_specialtyUterusHeterologousBiologyMiceGeneticsmedicineHomologous chromosomeAnimalsHumansMolecular BiologyAgedGeneticsChromosome AberrationsMixed Tumor MesodermalCytogeneticsChromosomeKaryotypeMiddle Agedmedicine.diseasePrimary tumormedicine.anatomical_structureIn uteroKaryotypingUterine NeoplasmsFemaleNeoplasm TransplantationCancer genetics and cytogenetics
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